(FILES) Food and Drug Administration (FDA) Commissioner Dr. Marty Makary speaks alongside US Health and Human Services (HHS) Secretary Robert F. Kennedy, Jr., as they announce the sending of warning letters to companies for illegally marketing products containing 7-hydroxymitragynine, also known as 7-OH, as part of their actions combatting opioids, during a press conference at HHS headquarters in Washington, DC, on July 29, 2025. President Donald Trump said on May 12, 2026, his US Food and Drug Administration chief, Marty Makary, is leaving his post, a departure that follows weeks of political tumult at the powerful agency. During his tenure atop the sprawling body responsible for overseeing vaccines, medicine and food, Makary managed to upset figures across industry, politics and public health over a range of issues, and most recently faced pressure from the Republican president to sign off on fruit-flavored vapes. (Photo by SAUL LOEB / AFP via Getty Images)